BCL 2 (Ab 70) Antilichaam

BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

596

P10415

NP_000624.2

Human

BCL-2 (Ab-70) antibody was raised against a peptide sequence around aa.68~72 (R-T-S-P-L) derived from Human BCL-2.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

26 kDa

This antibody detects endogenous level of total BCL-2 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

BCL2

B-cell CLL/lymphoma 2

Homo sapiens

Muller IM, et al. (2005) Mol Pharmacol. Jin Z, Gao F, et al. J Biol Chem 2004 Sep 17; 279 (38) : 40209-19. Kumar Biswas S, et al. Mol Cancer Ther 2004 Mar; 3 (3) : 327-34. Huang ST, et al. (2002) FASEB J; 16 (8) : 825-32. Yamamoto K, et al. (1999) Mol Cell Biol; 19 (12) : 8469-78.

Bcl-2, PPP1R50, PKR, PRKR, BCL2

WB, IHC, IF

72198189

Liquid