BCL-2 (fosfo Ser87) Antilichaam

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) .

596

P10415

NP_000624.2

Human, Mouse, Rat

BCL-2 (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine 87 (A-L-S (p) -P-V) derived from Human BCL-2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

28 kDa

IgG

The antibody detects endogenous level of BCL-2 only when phosphorylated at serine 87.

Western Blot: 1:500~1:1000

BCL2

B-cell CLL/lymphoma 2

Homo sapiens

Nencioni L, et al. (2009) J Biol Chem 284, 16004-15. Pattingre S, et al. (2009) J Biol Chem 284, 2719-28. Wei Y, et al. (2008) Mol Cell 30, 678-88.

Apoptosis regulator Bcl-2, BCL2

WB

72198189

Liquid