Bcl-2 Monoklonale Antilichaam, Biotinevervoeging

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release

Apoptosis regulator Bcl-2; BCL2

596

P10415

Human

Bcl-2

1A5

Biotin

Recombinant protein fragment (1-220 amino acids range) of human Bcl-2.

WB

Purified by Protein G.

1µg/µl

WB (1:300-5000)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

596