Bcl-G Antilichaam

Bcl-G Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G. The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.

79370

Q9BZR8

NM_030766

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

Bcl-G Antibody is Ion exchange chromatography purified.

Cat. No. 1215 - U937 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (92%)

Bcl-G Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Bcl-G antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Although antibody should react with both isoforms, only the Bcl-GS protein has been observed

BCL2L14

Cat. No. 1416 - Mouse Testis Tissue Lysate

BCL2-like 14 (apoptosis facilitator)

Homo sapiens

Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.

Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.. 2004; 39:1125-35.

Guo B, Godzik A, and Reed JC. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. J. Biol. Chem. 2000; 276:2780-5.

Bcl-G Antibody: BCLG, BCLG, Apoptosis facilitator Bcl-2-like protein 14, Apoptosis regulator Bcl-G, Bcl2-L-14

ELISA, WB, IHC-P, IF

13540528

Liquid