BCL XL (Ab 62) Antilichaam

Potent inhibitor of cell death. Isoform Bcl-X (L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X (S) isoform promotes apoptosis.

598

Q07817

NP_612815.1

Human, Mouse, Rat

BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

30 kDa

This antibody detects endogenous level of total BCL-XL protein.

Western Blot: 1:500~1:1000

BCL2L1

BCL2-like 1

Homo sapiens

Basu A, et. al. (2003) Mar 13; 538 (1-3) : 41-7Cheng E. H. -Y. et. al. (1996) Nature 379:554-556. Sattler M. et. al. (1997), Science 275:983-986. Muchmore S. W. et. al (1996) . Nature 381:335-341Yu J., Zhang L. Mol. (2001) Cell 7:673-682

BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, P53, Apoptosis regulator Bcl-X

WB

20336335

Liquid