BCL10 Antilichaam

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

8915

O95999

Human, Mouse

A synthetic peptide of human BCL10

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction

Affinity purification

Mouse ovary

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C (regular) or -20˚ C (long term) . Avoid freeze / thaw cycles.

Observed: 32kDa

IgG

BCL10

B-cell CLL/lymphoma 10

Homo sapiens

Bcl-10 Antibody: CLAP, mE10, CIPER, c-E10, CARMEN, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10

WB, IHC, IF, Flow

Liquid