BCL10 Antilichaam [4F8E8H8]

B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD) . It plays an important role in apoptosis and activating NF-κ B. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κ B signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κ B, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

8915

O95999

O95999

Human

Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3) .

4F8E8H8

Unconjugated

Primary Antibodies

Signal Transduction, Apoptosis

Antibody is purified by protein A affinity chromatography.

Batch dependent

None

Blue Ice

BCL-10 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

BCL10

B-cell CLL/lymphoma 10

Homo sapiens

Willis, T.G., et al. (1999) Cell. 96, 35-45.

Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019.

Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409

CIPER, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10, mE10, CIPER, c-E10, CARMEN

ELISA, WB, IHC

20454813

Liquid