BCL10 Mouse Monoclonal Antibody [Kloon ID: LBI4A8]

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Carrier-free (BSA/glycerol-free) BCL10 mouse monoclonal antibody, clone LBI4A8

C-E10; CARMEN; CIPER; CLAP; IMD37; mE10

Homo sapiens BCL10 immune signaling adaptor (BCL10), transcript variant 1, mRNA.

8915

O95999

Unconjugated

B cell receptor signaling pathway, T cell receptor signaling pathway

B cell receptor signaling pathway, T cell receptor signaling pathway

WB 1:2000, IHC 1:50, IF 1:100, FLOW 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

BCL10

https://www.ncbi.nlm.nih.gov/gene/?term=8915

https://www.uniprot.org/uniprot/O95999