BCL2A1 Antilichaam

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

597

Q16548

Human, Mouse, Rat

A synthetic peptide of human BCL2A1

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Immunology

Affinity purification

Mouse lung

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C. Avoid freeze / thaw cycles.

Observed: 20kDa

IgG

BCL2A1

BCL2-related protein A1

Homo sapiens

Bfl-1 Antibody: GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5, GRS, Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5

WB, IHC, Flow

Liquid