BCMA Antibody / CD269 / TNFRSF17

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells) . Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE) .

ELISA: order BSA/sodium azide-free format for coating, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

Q02223

Human

A portion of amino acids 78-184 from the human protein was used as the immunogen for the BCMA antibody.

BCMA/2366

ELISA, IHC-P

Protein G affinity chromatography

Purified

This BCMA antibody is available for research use only.

Store the BCMA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

1 mg/mL in 1X PBS; BSA free, sodium azide free

Titering of the BCMA antibody may be required for optimal performance.

Cell surface

IHC testing of FFPE human gastric carcinoma with BCMA antibody (clone BCMA/2366) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.