Bcr (fosfo-Tyr177) Antilichaam

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

613

P11274

NP_004318.3

Human, Mouse

Bcr (Phospho-Tyr177) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 177 (P-F-Y (p) -V-N) derived from Human Bcr.

Unconjugated

Primary Antibodies

Phospho-Specific, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

210 kDa

This antibody detects endogenous level of Bcr only when phosphorylated at tyrosine 177.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

BCR

Breakpoint cluster region

Homo sapiens

Sattler M, et al. Mol Cell Biol. 1999 Nov; 19 (11) : 7473-7480. Li S et al. EMBO J. 2001 Dec 3; 20 (23) : 6793-6804. Million RP, et, al. Mol Cell Biol. 2004 Jun; 24 (11) : 4685-4695. Malcolm A. Meyn, et al. . Biol. Chem., Oct 2006; 281: 30907 – 30916.

ALL, CML, PHL, BCR1, D22S11, D22S662, CFL, BCR, BCR protein

WB, IHC

82546843

Liquid