BD-1

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Murine BD-1 is a 4.1 kDa protein containing 37 amino acid residues.

Beta-Defensin 1, DEFB1, HBD1

13214

P56386

NP_031869.1

NM_007843.3

8 A2; 8 10.35 cM

Mouse

Mouse

DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS

< 0.1 ng/µg of protein (< 1EU/µg)

≥ 98% by SDS-PAGE gel and HPLC analyses.

Not available.

37

Lyophilized

4.1 kDa

E. coli