Beclin-1 Antilichaam

Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

8678

Q14457

AAH10276

Human, Mouse, Rat

3613

Unconjugated

Primary Antibodies

Antibody validated: Western Blot in human samples; Immunohistochemistry in human, mouse, and rat samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Apoptosis, Autophagy, Cancer

Beclin-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%)

Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Beclin-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human Beclin-1 has one isoform (450aa, 52kD) . Mouse Beclin-1 has one isoform (448aa, 52kD) and Rat Beclin-1 also has one isoform (448aa, 52kD) . 3613 can detect human, mouse and rat.

BECN1

Cat. No. 1403 - Mouse Brain Tissue Lysate

Beclin 1, autophagy related

Homo sapiens

Gozuacik et al. Oncogene. 2004; 23:2891-906.

Kisen et al. Carcinogenesis 1993; 14:2501-5.

Liang et al. J. Virol. 1998; 72:8586-96.

Kametaka et al. J. Biol. Chem. 1998; 273:22284-91.

Beclin-1 Antibody: ATG6, VPS30, beclin1, GT197, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein

ELISA, WB, IHC-P, IF

16307457

Liquid