Benzylhydrochloorthiazide

Benzylhydrochlorothiazide is an orally active thiazide diuretic. Benzylhydrochlorothiazide acts on the distal convoluted tubules of the kidneys, inhibiting the reabsorption of sodium chloride, thereby increasing urine output and reducing the body's fluid volume. Benzylhydrochlorothiazide has phototoxicity and a potential risk of skin reactions. Benzylhydrochlorothiazide can cause cell death when exposed to UVA radiation. Benzylhydrochlorothiazide is used in research on hypertension and edema[1].

1824-50-6

12352005

H302-H315-H319-H335

Sodium Channel

Membrane Transporter/Ion Channel

Cardiovascular Disease

O=S(C1=C(Cl)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O

C14H14ClN3O4S2

387.86

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Inamoto N, et al. Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis. J Am Acad Dermatol. 1984 Aug;11 (2 Pt 2) :357-61. |[2]Selvaag E, et al. Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics. J Photochem Photobiol B. 1997 Mar;38 (1) :88-93.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W587755/

Reference compound2

No Development Reported