BEST1 Antilichaam

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

7439

O76090

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience

Affinity purification

Mouse liver

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 68kDa

IgG

BEST1

Mouse lung

Bestrophin 1

Homo sapiens

ARB, BEST, BMD, Best1V1Delta2, RP5TU15B, VMD2, bestrophin-1, Best disease, vitelliform macular dystrophy protein 2

WB, IF

Liquid