Beta Arrestine 1 (ARRB1) Mouse Monoclonal Antibody [Kloon ID: LBI2B3]

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

Carrier-free (BSA/glycerol-free) ARRB1 mouse monoclonal antibody, clone LBI2B3

ARB1; ARR1

Homo sapiens arrestin beta 1 (ARRB1), transcript variant 1, mRNA.

408

P49407

Unconjugated

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

WB 1:500-2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

ARRB1

https://www.ncbi.nlm.nih.gov/gene/?term=408

https://www.uniprot.org/uniprot/P49407