Beta-arrestine 1 (ARRB1) (NM 004041) Humaan recombinant eiwit

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Purified recombinant protein of Human arrestin, beta 1 (ARRB1), transcript variant 1, full length, with N-terminal His tag, expressed in E. coli, 50ug

ARB1; ARR1

408

P49407, B7Z1Q3

NM_004041

11q13.4

E. coli

N-His

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

Chemokine signaling pathway, Endocytosis, MAPK signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0

Druggable Genome

46.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

ARRB1

Human

NP_004032

https://www.ncbi.nlm.nih.gov/gene/408

https://www.uniprot.org/uniprot/P49407

https://www.ncbi.nlm.nih.gov/nuccore/NM_004041

https://www.ncbi.nlm.nih.gov/nuccore/NP_004032