Beta Catenin Antibody, KO gevalideerd

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

1499

P35222

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 650-750 of human beta Catenin (NP_001895.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction, Stem Cell, Transcription

Affinity purification

Mouse lung

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 105kDa

IgG

CTNNB1

Rat testis

Catenin (cadherin-associated protein), beta 1, 88kDa

Homo sapiens

CTNNB1, CTNNB, MRD19, armadillo

WB, IHC, IP

Liquid