Betulin (GMP)

Betulin (GMP) (Trochol (GMP) ) is Betulin produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.

473-98-3

Trochol (GMP)

12352211

Apoptosis; Endogenous Metabolite; Fatty Acid Synthase (FASN)

Apoptosis; Metabolic Enzyme/Protease

Cancer

C=C(C)[C@@H]1CC[C@]2(CO)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H]

C30H50O2

442.72

[1]Król SK, et al. Comprehensive review on betulin as a potent anticancer agent. Biomed Res Int. 2015;2015:584189.|[2]Drag M, et al. Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines. Molecules. 2009 Apr 24;14 (4) :1639-51.|[3]Ma C, et al. Protective effect of betulin on cognitive decline in streptozotocin (STZ) -induced diabetic rats. Neurotoxicology. 2016 Dec;57:104-111.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N0083G/

GMP Small Molecules

No Development Reported