Betulonaldehyde

Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC50: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate induced inflammation in mice[1][2].

4439-98-9

12352211

Parasite

Anti-infection

Cancer; Infection; Inflammation/Immunology

O=C[C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@]([C@]4([C@]([C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC4)C)([H])CC3)C)(CC1)C

C30H46O2

438.69

[1]Wisetsai A, et al. Chemical constituents and their biological activities from the roots of diospyros filipendula. Nat Prod Res. 2021 Aug;35 (16) :2739-2743.|[2]Yasukawa K, et al. Some lupane-type triterpenes inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine. 1995 Apr;1 (4) :309-13.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N9475/

Natural Products

No Development Reported