BHLHA15 Antilichaam

BHLHA15 (basic helix-loop-helix protein 15), also known as MIST1 (muscle intestine and stomach expression 1) belongs to the bHLH family of transcription factors and plays a role in regulating the transcriptional activity of MYOD1 in muscle cell development as well as serving as a key regulator of acinar cell function (1,2) . BHLHA15 contains a basic helix-loop-helix (bHLH) domain and is capable of binding to E-box motifs as a homodimer or a heterodimer with E-proteins. It may also negatively regulate bHLH-mediated transcription through a N-terminal repressor domain (3) . It is expressed in mammary epithelial cells and is essential for the regulation of mammary gland development (4) .

168620

Q7RTS1

NP_803238

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

BHLHA15 antibody is affinity chromatography purified via peptide column.

Cat. No. 1468 - Rat Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (71%)

BHLHA15 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BHLHA15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

BHLHA15 antibody is human, mouse and rat reactive.

BHLHA15

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Basic helix-loop-helix family, member a15

Homo sapiens

Lemercier C, To RQ, Swanson BJ et al. MIST1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev. Biol. 1997; 182:101-13.

Pin CL, Rukstalis JM, Johnson C, et al. The bHLH transcription factor MIST1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 2001; 155:519-30.

Lemercier C, To RQ, Carrasco RA et al. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD. EMBO J. 1998; 17:1412-22.

Zhao Y, Johansson C, Tran T, et al. Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state. Mol. Endocrinol. 2006; 20:2187-98.

BHLHA15 Antibody: MIST1, BHLHB8, MIST1, Class A basic helix-loop-helix protein 15, Class B basic helix-loop-helix protein 8, bHLHa15

ELISA, WB, IHC-P, IF

29126247

Liquid