BI-D1870
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
BI-D1870 is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental autoimmune encephalomyelitis suggesting a new strategy to treat multiple sclerosis.2 BI-D1870 has also been found to alter mTORC1 signaling in an RSK-independent manner.3 BI-D1870 induced apoptosis in oral squamous cell carcinoma cells4, suppressed growth and induced apoptosis in pediatric medulloblastoma cell lines as well as sensitizing these lines to Sonic hedgehog agents5, and blocked cell proliferation and protein synthesis in dual BRAF and MEK inhibitor-resistant melanoma6.
Unconjugated
Off-white solid
-20°C
Beschrijving
BI-D1870 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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KBFP720 700L Stability Chamber
CHA3020
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KBFLQC240 247L Stability Chamber
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KBF1020 1020L Stability Chamber
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Stability Chamber KBFP240 247L
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Drug Stability Chamber
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Drug Stability Chamber
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1 Unit