BI605906
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
960293-88-3
C02098-5mg
IκB/IKK
NF-κB
BI605906 is a selective inhibitor of IKKβ with an IC50 of 380 nM when assayed at 0.1 mM ATP, suppressing the phosphorylation and activation of IKKβ, modulating NF-κB signalling. It also inhibits the insulin-like growth factor 1 (IGF1) receptor, with an IC50 of 7.6 μM. BI605906 effectively blocks TNF-α-dependent IκB degradation and reduces the expression of proinflammatory cytokines, including IL-6, IL-1β, and C-X-C motif ligands CXCL1/2.
Beschrijving
BI605906 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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