BICD1 Antilichaam

BICD1 Antibody: BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

636

Q96G01

NP_001705

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

BICD1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1224 - Daudi Cell Lysate

1 mg/mL

BICD1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BICD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of BICD1 are known to exist; this antibody will only recognize the larger isoform.

BICD1

Bicaudal D homolog 1 (Drosophila)

Homo sapiens

Baens M and Marynen P. A human homologue (BICD1) of the drosophila bicaudal-D gene. Genomics1997; 45:601-6.

Matanis T, Akhmanova A, Wulf P, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat. Cell Biol.2002; 986-92.

Wanshers BF, van de Vorstenbosch R, Schlager MA, et al. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. Exp. Cell Res.2007; 313:3408-20.

BICD1 Antibody: BICD, Protein bicaudal D homolog 1, Bic-D 1

ELISA, WB, ICC, IF

51039802

Liquid