Biotine- (Oaa) 3-epoxomicine

Biotin- (Oaa) 3-epoxomicin (Compound 13) is a biotinylated active form of Epoxomicin. Biotin- (Oaa) 3-epoxomicin is a high affinity probe targeting Proteasome. Biotin- (Oaa) 3-epoxomicin covalently binds to multiple proteasome catalytic subunits (such as LMP7, Z and MECL1).

247068-92-4

12352209

Proteasome

Metabolic Enzyme/Protease

Others

O=C([C@]1(CO1)C)[C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)N(C)C(CCCCCNC(CCCCCNC(CCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)=O)=O)=O)=O)=O

C54H95N9O11S

1078.45

[1]Sin N, et al. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett. 1999 Aug 2;9 (15) :2283-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11306/

Peptides

No Development Reported