BL-CAM (fosfo-Tyr807) Antilichaam

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

933

P20273

NP_001762.2

Human

BL-CAM (phospho Tyr807) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y (p) -E-N) derived from Human BL-CAM.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

95 kDa

IgG

The antibody detects endogenous levels of BL-CAM only when phosphorylated at tyrosine 807.

Western Blot: 1:500~1:1000

CD22

CD22 molecule

Homo sapiens

Wilson G.L., J. Exp. Med. 173-137-146 (1991) .

Wilson G.L., J. Immunol. 150:5013-5024 (1993) .

Stamenkovic I., Nature 345-74-77 (1990) .

Siglec-2, B-cell receptor CD22, BL-CAM, Leu-14, B-lymphocyte cell adhesion molecule

WB

157168355

Liquid