BLK Antilichaam (9D10D1]

BLK (B lymphoid tyrosine kinase), with 505-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

640

P51451

P51451

Human

Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3) .

9D10D1

Unconjugated

Primary Antibodies

Apoptosis

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

BLK monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2a

BLK

B lymphoid tyrosine kinase

Homo sapiens

Theresa Tretter, Ashley E. Ross, Dominic I. Dordai. J. Exp. Med., Dec 2003; 198: 1863.

B lymphocyte kinaseMODY11

ELISA, WB, IHC

158936749