BLK (fosfo Tyr501) Antilichaam

Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor.

640

P51451

NP_001706.2

Human, Mouse

BLK (phospho Tyr501) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y (p) -E-L) derived from Human BLK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

57 kDa

IgG

The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501.

BLK

B lymphoid tyrosine kinase

Homo sapiens

Islam K.B., J. Immunol. 154:1265-1272 (1995) .

Drebin J.A., Oncogene 10:477-486 (1995) .

Greenman C., Nature 446:153-158 (2007) .

P55-BLK, EC 2.7.10.2, kinase Blk, B lymphocyte kinase, Tyrosine-protein kinase BLK

IHC

33469982

Liquid