BLMH Antilichaam - middelste regio : HRP (ARP56106_P050-HRP)

Bleomycin hydrolase

BH, BMH

642

Q13867

NP_000377

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human BLMH

The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

NUDT12; WDYHV1; BLMH; UBC; ZBTB1; SH3GLB2; LZTFL1; GORASP2; PES1; GTF2A1; AP1M2; CYP2C8; RNF32; ECSIT; MAST1; COPS5; CUL4B; SUMO2; PDPK1; Fam134a; USP53; KBTBD7; RPL11; UBE2I; TRIO; RPL29; APP

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

BLMH is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

De (2008) J. Clin. Oncol. 26 (11), 1817-1823

Wet Ice

455

BLMH

BLMH

Rabbit

Bleomycin hydrolase

NM_000386

EYLSNMVGGRKTLYNNQPIDFLKKMVAASIKDGEAVWFGCDVGKHFNSKL