Bloedplaatjes glycoproteïne 4 Antilichaam / CD36

Recognizes a protein of 80kDa-90kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN) . CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL

P16671

Human

A portion of amino acids 200-400 from human Platelet glycoprotein 4 protein was used as the immunogen for the Platelet glycoprotein 4 antibody.

CD36/7216

IHC-P, WB

Protein A/G affinity

Purified

This Platelet glycoprotein 4 antibody is available for research use only.

Aliquot the Platelet glycoprotein 4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the Platelet glycoprotein 4 antibody should be determined by the researcher.

Cell membrane, Cytoplasm (Golgi)

IHC staining of FFPE human spleen tissue with Platelet glycoprotein 4 antibody (clone CD36/7216) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.