BM 170249

BM 170249 is a peroxisome proliferator, particularly in the perivenous region of the central acini in the liver. BM 170249 significantly reduces serum triglyceride and cholesterol levels in rats. BM 170249 strongly induces the activity of key enzymes in the peroxisome fatty acid β-oxidation system (such as acyl-CoA oxidase AOX, multifunctional enzyme PH, and thiolase PT), but leads to decreased activity of catalase and uricase in peroxisome components. BM 170249 could be used in lipid-lowering studies[1].

153655-35-7

12352211

PPAR

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Cardiovascular Disease

O=C(O)C(Cl)(Cl)CCCCCCCCCCC(Cl)(Cl)C(O)=O

C14H22Cl4O4

396.13

[1]Lindauer M, et al. Zonal heterogeneity of peroxisomal enzymes in rat liver: differential induction by three divergent hypolipidemic drugs. Hepatology. 1994 Aug;20 (2) :475-86.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19227/

Reference compound1

No Development Reported