Bmf Antilichaam

Bmf Antibody: Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) . The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.

90427

Q96LC9

NP_277038

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

Bmf Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (92%)

Bmf Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Bmf antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

BMF

Cat. No. 1211 - HepG2 Cell Lysate

Cat. No. 1201 - HeLa Cell Lysate

Cat. No. 17-001 - HeLa Cell Slide

Bcl2 modifying factor

Homo sapiens

Puthalakath H, Villunger A, O'Reilly LA, et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 2001; 293:1829-32.

Hunt A and Evan G. Apoptosis. Till death us do part. Science 2001; 293:1784-5.

Bmf Antibody: Bcl-2-modifying factor

ELISA, WB, ICC

15723378

Liquid