BMH-21
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
Unconjugated
Orange solid
-20°C
Beschrijving
BMH-21 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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