BMI-1 Antilichaam

BMI-1 Antibody: The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.

648

P35226

P35226

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

BMI-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)

BMI-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BMI-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

BMI1

Cat. No. 17-004 - K-562 Cell Slide

BMI1 polycomb ring finger oncogene

Homo sapiens

Alkema MJ, Wiegant J, Raap AK, et al. Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum. Mol. Genet. 1993; 2:1597-603.

Jacobs JJ, Kieboom K, Marino S, et al. The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999; 397:164-8.

Lessard J and Sauvageau G. BMI-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003; 255-60.

BMI-1 Antibody: PCGF4, RNF51, FLVI2/BMI1, PCGF4, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4

ELISA, WB, ICC, IF

22258801

Liquid