BMP-4 (acetaat)

BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. BMP-4 acetate regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages[1].

12352209

COX; IFNAR; Interleukin Related

Immunology/Inflammation

COVID-19-immunoregulation

Inflammation/Immunology

99.30

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N.CC(O)=O.[x]

C52H93N25O13S.xC2HFO2

1308.52 (free base)

[1]Pathade V, et al. Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sci. 2023 Jan 1;312:121257.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10710A/BMP-4-acetate-SDS-MedChemExpress.pdf

Peptides

No Development Reported

COX-2; IL-6