BMPR2 Antilichaam

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50

Q13873

Human, Mouse

A portion of amino acids 27-56 from the human protein was used as the immunogen for this BMPR2 antibody.

IHC, FACS, ELISA

Purified

Purified

This BMPR2 antibody is available for research use only.

Aliquot the BMPR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the BMPR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

IHC analysis of FFPE human hepatocarcinoma tissue stained with BMPR2 antibody