Boc-PEG2-Val-Cit-PAB-OH
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2055024-55-8
ADC Linker
Antibody-drug Conjugate/ADC Related
Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.
[C@H](C(NC1=CC=C(CO)C=C1)=O)(NC([C@@H](NC(CCOCCOCCNC(OC(C)(C)C)=O)=O)[C@H](C)C)=O)CCCNC(N)=O
C30H50N6O9
638.753
Ice Packs
-20°C
Beschrijving
Boc-PEG2-Val-Cit-PAB-OH Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
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