Boc-PEG2-Val-Cit-PAB-OH

Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

2055024-55-8

12352203

H302-H315-H319

ADC Linker

Antibody-drug Conjugate/ADC Related

Cancer

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(OC(C)(C)C)=O)=O)=O)=O

C30H50N6O9

638.75

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W800624/

ADC Related

No Development Reported