Boerelasin E
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21 (22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC50=20.52 μM) more potent than cisplatin. Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis[1].
12352005
Apoptosis
Apoptosis
Cancer-programmed cell death
Cancer
C=C1[C@@H](O)[C@@](/C=C/C[C@H](C)CCCC(/C=C\2)=O)([H])[C@]([C@@]3([H])[C@@H]1C)(OC2=O)C(N[C@H]3CC4=CC=CC=C4)=O
C29H35NO5
477.59
[1]Tian C, et al. Discovery of highly oxygenated cytochalasans with antiproliferative activity from an endophytic fungus Boeremia exigua. Bioorg Chem. 2025 Mar;156:108198.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-N15306/
Natural Products
No Development Reported
Beschrijving
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21 (22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin
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