BOK Antilichaam

BOK Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. BOK, a pro-apoptotic Bcl-2 family member, was initially identified in the ovary, and was found to interact with other Bcl-2 family members such as Mcl-1 and Bfl-1. BOK expression is high during early placental development, suggesting that it may also play a role in regulating trophoblast cell proliferation.

666

Q9UMX3

AAH06203

Human

Unconjugated

Primary Antibodies

Apoptosis

BOK Antibody is affinity chromatography purified via peptide column.

Cat. No. 10-301 - Human Brain Tissue Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%), Chicken: (81%)

BOK Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BOK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of BOK are known to exist; this antibody will not detect the smallest isoform. BOK antibody is predicted to not cross-react with other Bcl-2 protein family members

BOK

BCL2-related ovarian killer

Homo sapiens

Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.

Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.

Hsu SY, Kaipia A, McGee E, et al. bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA 1997; 94:12401-6

Soleymanlou N, Wu Y, Wang JX, et al. A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ. 2005; 12:441-52.

BOK Antibody: BOKL, BCL2L9, Bcl-2-related ovarian killer protein, Bcl-2-like protein 9, hBOK

ELISA, IHC-P

14210524

Liquid