Bora Antilichaam

Bora Antibody: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

79866

Q6PGQ7

Q6PGQ7

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Bora Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Bora Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Bora antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

BORA

Bora, aurora kinase A activator

Homo sapiens

Berdnik D and Knoblich JA. Drosophila Aurora A is required for centrosome maturation and Actin-dependent asymmetric protein localization during mitosis. Curr. Biol.2002; 12:640-647.

Wiese C and O'Brien LL. What's so Bor (a) ing about Aurora A activation? Dev. Cell2006; 11:133-134.

Hutterer A, Berdnik D, Wirtz-Peitz F, et al. Mitotic activation of the kinase Aurora A requires its binding partner Bora. Dev. Cell2006; 11:147-157.

Fu J, Bian M, Jiang Q, et al.. Roles of Aurora kinases in mitosis and tumorigenesis. Mol. Cancer Res.2007; 5:1-10.

Bora Antibody: C13orf34, C13orf34, Protein aurora borealis, HsBora

ELISA, WB, IHC-P, IF

74737659

Liquid