BPD
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC50 of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional level. BPD has anti-inflammatory activity. BPD can inhibit Carrageenan-induced paw oedema and LPS-induced septic death[1].
213481-12-0
12352005
COX; NF-κB
Immunology/Inflammation; NF-κB
Inflammation/Immunology
O=C1OC(C(C2=CC3=C(OCO3)C=C2)=C1C4=CC=CC=C4)=O
C17H10O5
294.26
[1]Shin JS, et al. Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, BPD, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-κB inactivation. Br J Pharmacol. 2012 Mar;165 (6) :1926-1940.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W995241/
Reference compound1
No Development Reported
Beschrijving
BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC50 of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional le
Specificaties
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Each
MS pipette, variable vol µme 10~100 µL
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MS 12-ch pipette, variable vol µme 20~200 µL
MSP-12X200
1 Unit
MS 12-ch pipette, variable vol µme 2~20 µL
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MS-NRK-3001
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MS Orbital Shaker with 30 x 30 cm platform and flat non-slip rubber mat
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MS pipette, variable vol µme 1000~10000 µL
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