BRCC3 Antilichaam - C-terminaal gebied: Biotine (ARP61990 P050-Biotine)

BRCA1/BRCA2-containing complex, subunit 3

C6.1A, BRCC36, CXorf53

79184

P46736

NP_077308

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.

FAM175B; UBC; FANCG; UIMC1; SUMO1; RABEP2; SMEK1; LARP7; CD2AP; WDHD1; SF3A1; GPHN; HNRNPR; TRIM28; HUWE1; MTA2; SPAG9; CCDC6; HDAC1; NR3C1; FAM175A; SUMO2; PAXIP1; MDC1; BRCA1; GRB2; BABAM1; BRE; BRCC3; COPS5; BACH1; BRCA2; BARD1; USP7; SHMT2; NDUFA10; M

Biotin

Polyclonal Antibody

IF, WB

Affinity Purified

BRCC3 is strongly supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

35kDa

Wet Ice

316

BRCC3

BRCC3

Rabbit

Lys-63-specific deubiquitinase BRCC36

NM_024332

HNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQEL