Brilacide (tetrahydrochloride)

Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin tetrahydrochloride is a defensin mimetic antibiotic compound[1][2].

1224095-99-1

PMX 30063 (tetrahydrochloride)

12352005

H228, H252, H290, H315, H319

Antibiotic; Bacterial

Anti-infection

COVID-19-immunoregulation

Infection; Cancer

10mM

99.10

DMSO : 83.33 mg/mL (ultrasonic) |Methanol : 10 mg/mL (ultrasonic)

O=C(C1=NC=NC(C(NC2=CC(C(F)(F)F)=CC(NC(CCCCNC(N)=N)=O)=C2O[C@H]3CNCC3)=O)=C1)NC4=CC(C(F)(F)F)=CC(NC(CCCCNC(N)=N)=O)=C4O[C@H]5CNCC5.Cl.Cl.Cl.Cl

C40H54Cl4F6N14O6

1082.75

H228, H252, H290, H315, H319

[1]Bruk Mensa , et al. Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16. Antimicrob Agents Chemother. 2014 Sep;58 (9) :5136-45.|[2]Regis P Kowalski, et al. An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-infective. J Ocul Pharmacol Ther. Jan-Feb 2016;32 (1) :23-7.

Room Temperature

4°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-19892A/Brilacidin-tetrahydrochloride-SDS-MedChemExpress.pdf

Reference compound1

Phase 2