BRL-32872
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells) . BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) [1].
113241-47-7
12352005
Potassium Channel
Membrane Transporter/Ion Channel
Cardiovascular Disease
O=C(N(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C3=CC=C([N+]([O-])=O)C=C3.Cl
C29H36ClN3O7
574.07
[1]Thomas D, et al. High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J Pharmacol Exp Ther. 2001 May;297 (2) :753-61.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19117/
Reference compound1
Phase 2
Beschrijving
BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells) . BRL-
Specificaties
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