BRL-52656

BRL-52656 is a blood-brain barrier (BBB) -penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) [1][2].

115642-84-7

12352005

Opioid Receptor

GPCR/G Protein; Neuronal Signaling

Cardiovascular Disease

FC(F)(F)C(C=C1)=CC=C1CC(N(CCCC2)[C@@H]2CN3CCCC3)=O.Cl

C19H26ClF3N2O

390.87

[1]Brooks DP, et al. Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther. 1993 Jul;266 (1) :164-71.|[2]Sako MO, et al. Filtering the Signal: Kappa Opioid Receptors in the Kidney. Function (Oxf) . 2025 Sep 15;6 (5) :zqaf042.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19070/

Reference compound1

Phase 1

κ Opioid Receptor/KOR