BRUCE Antilichaam

BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

57448

Q9NR09

NP_057336

Human

Unconjugated

Primary Antibodies

Apoptosis

BRUCE Antibody is affinity chromatography purified via peptide column.

Cat. No. 11-801 - Human Small Intestine Tissue Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (100%)

BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BRUCE antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

534 kDa

IgG

BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

BIRC6

Baculoviral IAP repeat-containing protein 6

Homo sapiens

Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004; 64:7183-90.

Chen Z, Naito M, Hori S, et al. A human IAP-gamily gene, apollon, expressed in human brain cancer cells. Biochem. Biophys. Res. Commun. 1999; 264:847-54

Hao Y, Sekine K, Kawabata A, et al. Apollon ubiquitinates SMAC and Caspase-9, and has an essential cytoprotection function. Nat. Cell Biol. 2004; 6:849-60.

BRUCE Antibody: BRUCE, APOLLON, KIAA1289, Baculoviral IAP repeat-containing protein 6, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE

ELISA, IHC-P

153792694

Liquid