Bruceoside D

Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers[1].

167782-22-1

12352005

Microtubule/Tubulin

Cell Cycle/DNA Damage; Cytoskeleton

Cancer

OC([C@@]1([C@H]2O)[C@@]([C@H]3OC(/C=C(C)/C)=O)([H])[C@@]([C@@](OC3=O)([H])C[C@@]4([H])[C@@H](C5=O)C)(CO1)[C@@]([C@H]2O)([H])[C@]4(C=C5O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]([C@H]6O)CO)C)=O

C31H40O16

668.64

[1]Ohnishi S, et al. Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica. J Nat Prod. 1995 Jul;58 (7) :1032-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16507/

Natural Products

No Development Reported