BTK-antilichaam

BTK Antibody: Bruton's tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia, and has since been shown to involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

695

Q06187

Q06187

Human, Mouse

Unconjugated

Primary Antibodies

Innate Immunity

BTK Antibody is affinity chromatography purified via peptide column.

Cat. No. 1215 - U937 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

BTK Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BTK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Multiple isoforms of BTK are known to exist.

BTK

Cat. No. 1224 - Daudi Cell Lysate

Bruton agammaglobulinemia tyrosine kinase

Homo sapiens

Vetrie D, Vorechovsky I, Sideras P, et al. The gene involved in X-linked aγ globulinaemia is a member of the src family of tyrosine kinases. Nature 1993; 361:226-33.

Kawakami Y, Kitaura J, Hata D, et al. Functions of Bruton's tyrosine kinase in mast and B cells. J. Leukoc. Biol. 1999; 65 (3) :286-90.

Jefferies CA, Doyla S, Brunner C, et al. Bruton's tyrosine kinase is a Toll/Interleukin-1 receptor domain-binding protein that participates in nuclear factor kB activation by Toll-like receptor 4. J. Biol. Chem. 2003; 278:26258-26264.

Akira S and Takeda K. Toll-like receptor Signalling. Nat. Rev. Immunol. 2004; 4:499-511.

BTK Antibody: AT, ATK, BPK, XLA, IMD1, AGMX1, PSCTK1, Tyrosine-protein kinase BTK, Agammaglobulinemia tyrosine kinase

ELISA, WB, IHC-P, ICC, IF

547759

Liquid