BTK-antilichaam (7F12H4]

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

695

Q06187

Q06187

Human

Ni-NTA purified truncated recombinant BTK expressed in E. Coli strain BL21 (DE3) .

7F12H4

Unconjugated

Primary Antibodies

Signal Transduction, Innate Immunity

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

BTK monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

BTK

Bruton agammaglobulinemia tyrosine kinase

Homo sapiens

Yamada, N., et al. Biochem. Biophys. Res. Commun. 192: 231-240.

Thomas, J.D., et al. 1993. Science. 261: 355-358.

Tamagnone, L., et al. Oncogene 9: 3683-3688.

AGMX1, ATK, BPK, Agammaglobulinemia tyrosine kinase, AT, XLA, IMD1, AGMX1, PSCTK1

ELISA, WB, IHC

547759